18 Deadliest Diseases Recorded in History

Throughout history, humans have faced many deadly diseases. Some of these illnesses have wiped out entire communities, changed the course of wars, and shaped the world we live in today. From ancient plagues to modern pandemics, these diseases have left their mark on human society. Let’s take a look at 18 of the deadliest diseases ever recorded.

Bubonic Plague (Black Death)

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This disease killed about a third of Europe’s population in the 14th century. It’s spread by fleas that live on rats. Symptoms include fever, chills, and painful swollen lymph nodes called buboes. While it’s rare now, it still exists in some parts of the world.

Smallpox

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Smallpox caused fever and a skin rash that left scars. It killed millions of people throughout history and wiped out many Native American populations. Thanks to vaccines, it was declared eradicated in 1980.

Spanish Flu

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This flu pandemic in 1918-1919 infected about a third of the world’s population. It was unusually deadly for young adults. It killed more people than World War I, with estimates ranging from 20 to 50 million deaths.

HIV/AIDS

This virus weakens the body’s defence system, leaving it vulnerable to infections. Without treatment, it can progress to AIDS. Although incurable, current medical advancements enable those infected to maintain long-term health and average lifespans.

Tuberculosis (TB)

This disease primarily impacts the lungs, though it can harm other body parts as well. It has existed for millennia. While antibiotics can treat it, the emergence of drug-resistant varieties is becoming an increasing worry.

Malaria

Malaria, a disease transmitted by mosquitoes carrying parasites, induces symptoms resembling the flu, including fever and chills. This illness has been a significant cause of mortality throughout human history and continues to claim hundreds of thousands of lives annually, with Africa bearing the brunt of its impact.

Cholera

Bacillus of Hog Cholera” by Ephemeral Scraps is licensed under CC BY 2.0.

This disease causes severe diarrhea and dehydration. It’s spread through contaminated water. Cholera has caused many outbreaks throughout history and remains a problem in areas with poor sanitation.

Typhoid Fever

Spread through contaminated food and water, typhoid causes high fever, weakness, and stomach pain. It was a major killer before modern sanitation and antibiotics. Some people, like “Typhoid Mary,” can spread it without showing symptoms.

Yellow Fever

This viral disease is spread by mosquitoes. It causes fever, nausea, and, in severe cases, liver damage, leading to yellow skin. It was a significant problem in tropical areas until a vaccine was developed in the 1930s.

Polio

Polio Virus” by vitroid is licensed under CC BY 2.0.

Polio can cause paralysis and was once a significant fear for parents. Thanks to vaccines, it’s been eliminated in most countries. However, it still exists in a few places, showing why vaccination is important.

Ebola

Ebola Virus Particles” by NIAID is licensed under CC BY 2.0.

This viral infection leads to severe internal and external hemorrhaging. Outbreaks have primarily been confined to African regions. Although uncommon, Ebola’s high mortality rate and the intensity of its symptoms often trigger widespread alarm during outbreaks.

Influenza

influenza virus” by kat m research is licensed under CC BY-SA 2.0.

The flu might seem common, but some strains can be very deadly. Every year, it kills thousands of people, especially the elderly and those with weak immune systems. New strains can cause pandemics, like the 2009 swine flu.

Measles

Before vaccines, almost everyone got measles as a child. While often mild, it can cause serious complications. It’s still a major killer in developing countries and is making a comeback where vaccination rates have dropped.

Pneumonia

This lung infection can be caused by viruses, bacteria, or fungi. It’s especially dangerous for young children and older adults. Even today, it’s a leading cause of death in children under five worldwide.

Diphtheria

This bacterial infection can cause a thick coating in the back of the throat, making it hard to breathe. Before a vaccine was developed, it was a major cause of death in children. It’s rare now but still exists.

Whooping Cough (Pertussis)

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It is a severe respiratory infection characterized by intense bouts of coughing. This highly transmissible illness poses a particular threat to infants and could potentially prove fatal. Despite the availability of a preventive vaccine, the disease continues to emerge in outbreaks, particularly in areas with low immunization coverage.

Rotavirus

Rotavirus 2” by Dr Graham Beards is licensed under CC BY-SA 4.0.

This virus causes severe diarrhea in young children. Before a vaccine was developed, it killed hundreds of thousands of children each year. It’s still a serious problem in countries where the vaccine isn’t widely available.

COVID-19

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A respiratory virus that appeared in late 2019 swiftly became a global concern. This coronavirus can cause serious illness, particularly in older individuals. Its rapid spread led to a worldwide health crisis, resulting in millions of fatalities and widespread disruption to normal life across the planet.

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Mary Apurong

Mary Apurong is an experienced editor and ghostwriter who enjoys writing and reading. She loves researching topics related to life and creating content on quotes, gardening, food, travel, crafts, and DIY. Mary spends her free time doing digital art and watching documentaries.

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